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Scientists develop nutritional supplement to treat drug-resistant epilepsy


The first clinical trial of a new nutritional treatment for children and adults with severe forms of epilepsy, which was co-developed by UCLA researchers and based on the keto diet, has completed, according to a report in the Journal of Neuroscience, a new oral nutrient based on the keto diet to treat seizures by up to 50% in children and adults with drug-resistant epilepsy.


The study, published in Brain Communications, revealed that doctors evaluated the use of the treatment, an oral liquid nutritional supplement.


The keto diet consists of high fat, low carbohydrate, adequate protein consumption and mimics a fasting state, which alters the metabolism to use body fat as the primary source of energy. This shift from carbohydrates to fats as fuel for the body is known as ketosis.


It is widely used to treat drug-resistant epilepsy However, a highly restrictive diet, which can cause constipation, low blood sugar and stomach problems, can have poor compliance and is not suitable for everyone. Some diabetes supplements are also known to be unappetizing. .



The new treatment builds on new findings from University of California researchers, who have discovered a different underlying mechanism to explain why the keto diet is effective in combating epilepsy. In developing a new treatment, researchers also sought to reduce the harmful side effects caused by the keto diet.


Corresponding author Professor Matthew Walker of the Queen Square Institute of Neurology at UCLA said: "The ketogenic diet has been used for 100 years to treat epilepsy, helping to reduce seizures in both children and adults.

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