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A study reveals proteins responsible for the development of Alzheimer's disease and memory loss

A study issued by the Mayo Clinic revealed the gene responsible for the development of Alzheimer's disease, as it was found that the gene encoding a protein called SERPINA5 may exacerbate the tangle of another protein called tau, which leads to the development of the disease, according to what was published by Medical Express.


The researchers based on data from study participants, and brain tissue samples were taken, in order to verify the gene's link with Alzheimer's disease, as the researchers used tissue samples from 385 brains donated to the Mayo Clinic Brain Bank, which includes more than 9,000 brain tissue samples for a study. Neurodegenerative disorders.

The researchers used these samples to classify the protein synapse pattern associated with Alzheimer's disease, and RNA sequences were used to determine the gene expression in the samples, which effectively measure the genetic changes responsible for directing the proteins that lead to Alzheimer's disease.


The researchers found a complete disease spectrum and genetic changes that affect the hippocampus area, which is the brain's memory center, revealing that some patients have a relative preservation of memory, while some people have a relative exacerbation of memory loss symptoms.

The study aims to identify the proteins and genes related to Alzheimer's disease, with the aim of finding new therapeutic mechanisms that contribute to treating the disease.